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Title   유방암에서 현미 부수체 불안정성 ( Microsatellite Instability ) 의 발현이 예후에 미치는 영향 ( Microsatellite Instability Correlate with a Prognosis in Breast Cancer )
Publicationinfo   1998 Jan; 030(05): 914-921.
Key_word   Breast cancer, Microsatellite instability, Replication error, TGF-￥a, TGF-￥a RII
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Abstract   Purpose: Microsatellite instability in patients with defects in the mismatch repair system resulting in RER has a high risk of accumulating mutations in oncogene and tumor suppressor gene. In this study, we evaluated the incidence of microsatellite instability in breast cancer by comparing PCR-amplified sequences from frozen samples of normal and tumor tissue fram affected patients. We also investigated whether RER was associated with TGF-￥a RII mutation. Materials and Methods: Fifty surgically resected breast cancer specimens from Jan. 1996 to June, 1997 were used for study. Microsatellite instability(referred to as replication error, RER) at three loci with BAT 26, BAT 40, TA10 was analyzed by polymerase chain reaction and the results were compared with clinicopathologic characteristics. Results: Of the 50 breast cancer patients, 14(28%) were RER(+) at one or more microsatellite loci, and 4(8%) showed TGF-￥a RII mutation. Microsatellite instability was significantly correlated with lymph node involvement(especially in case of 4 or more lymph nodes involvement). But we could not find any correlation between RER and other prognostic factors including tumor size, tumor grade, hormone receptor status and pathology. One of fourteen tumors with RER(+) showed TGF-￥a RII mutstion. There was no signiticant correlation between RER(+) and TGF-￥a type II receptor gene mutation. Conclusion: The findings suggest that microsatellite instability would be useful prognostic factor in unilateral breast cancer patients, and the role of targeting to gene mutation will be explored in future studies.
저 자   이화영(Hwa Young Lee),전성실(Chengshi Quan),공수정(Soo Jung Gong),박준오(Joon Oh Part),안중배(Joong Bae Ahn),심광용(Kwang Yong Shim),라선영(Sun Young Rha(,윤0춘(Nae Choon Yoo),양우익(Woo Ick Yang),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),이경식(Kyong Sik Lee),김병수(Byung Soo Kim),정현철(Hyun